Related Experiment Videos
[A study on the role of immunosuppression in the pathogenesis of brucellosis]
1Institute of Epidemiology & Microbiology, Chinese Academy of Preventive Medicine, Beijing.
An immunosuppressive effect was seen in murine brucellosis as detected by using plaque forming cell (PFC) and 3H-labelled lymphocyte blastogenesis transformation (LBT) assays. The immunosuppression PFC could last until 11 months after infection, while that of LBT was only seen at 3 months after infection. This immunosuppression could be relieved by using immunomodulators such as levamisole, bestatin, IL-2 and polyporus umbellatus. IL-2 and polyporus umbellatus could reverse the suppression to normal levels. Thus, this study provided evidence that immunosuppression is a component of pathogenesis of brucellosis.
An immunosuppressive effect was seen in murine brucellosis as detected by using plaque forming cell (PFC) and 3H-labelled lymphocyte blastogenesis transformation (LBT) assays. The immunosuppression PFC could last until 11 months after infection, while that of LBT was only seen at 3 months after infection. This immunosuppression could be relieved by using immunomodulators such as levamisole, bestatin, IL-2 and polyporus umbellatus. IL-2 and polyporus umbellatus could reverse the suppression to normal levels. Thus, this study provided evidence that immunosuppression is a component of pathogenesis of brucellosis.