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Endogenous digitalis-like factors.

W Schoner1

  • 1Institut für Biochemie und Endokrinologie, Fachbereich Veterinärmedizin, Justus-Liebig-Universität Giessen, Federal Republic of Germany.

Clinical and Experimental Hypertension. Part A, Theory and Practice
|January 1, 1992
PubMed
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Mammals, including humans, may synthesize cardiac glycosides like ouabain and digoxin in their adrenal glands and hypothalamus. These endogenous compounds may play a role in regulating blood pressure.

Area of Science:

  • Biochemistry
  • Physiology
  • Endocrinology

Background:

  • A natriuretic factor inhibiting the kidney's sodium pump suggests endogenous regulators of sodium balance.
  • Elevated levels of digitalis-like factors are observed in conditions such as salt loading, essential hypertension, pregnancy-induced hypertension, and chronic hypervolemia.

Purpose of the Study:

  • To explore the synthesis and potential roles of endogenous cardiac glycosides in mammals.
  • To investigate the presence and function of compounds similar to ouabain and digoxin in human physiology.

Main Methods:

  • Isolation of ouabain or its isomer from human plasma.
  • Demonstration of a digoxin-like compound in adrenal glands and human urine.
  • Investigation of hypothalamic compounds binding to cardiac glycoside receptors.

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Main Results:

  • Endogenous cardiac glycosides, ouabain and digoxin-like substances, have been identified in mammals.
  • Evidence suggests synthesis occurs in adrenal glands and potentially the hypothalamus.
  • Other compounds binding to cardiac glycoside receptors are formed in the hypothalamus.

Conclusions:

  • Mammals may synthesize cardiac glycosides, similar to non-vertebrates and toads.
  • The precise physiological roles of endogenous ouabain and digoxin-like substances in blood pressure regulation require further elucidation.
  • Further research is needed to understand the differential functions of these endogenous compounds.