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Pasteurella pseudotuberculosis infection in man

S I HNATKO, A E RODIN

    Canadian Medical Association Journal
    |June 1, 1963
    PubMed

    Insights

    Pasteurella pseudotuberculosis infections, often mistaken for appendicitis, were detected in over 20% of patients. High antibody titers confirmed active mesenteric lymphadenitis in some cases, indicating this bacterium is a significant cause of human illness.

    Area of Science:

    • Medical Microbiology
    • Infectious Diseases
    • Human Pathology

    Background:

    • Pasteurella pseudotuberculosis is a known animal pathogen with recently recognized human disease potential.
    • Human infections manifest as acute septicemia or mesenteric lymphadenitis.
    • Mesenteric lymphadenitis symptoms often mimic acute appendicitis, complicating diagnosis.

    Purpose of the Study:

    • To investigate the prevalence of Pasteurella pseudotuberculosis infection in patients undergoing appendicitis surgery.
    • To determine the diagnostic utility of agglutinin testing for P. pseudotuberculosis in differentiating mesenteric lymphadenitis from appendicitis.

    Main Methods:

    • Serum samples from 66 patients operated on for appendicitis were tested for agglutinins against seven P. pseudotuberculosis serotypes.
    • Titers were analyzed to identify active infection versus past exposure.
    • P. pseudotuberculosis was isolated from a lymph node in one appendicitis case.

    Main Results:

    • Agglutinins to P. pseudotuberculosis were detected in 21.2% of the patient series.
    • High antibody titers (over 1/100) were found in all confirmed mesenteric lymphadenitis cases and in one appendicitis case.
    • Low antibody titers (1/15 or less) suggested previous exposure in several appendicitis and control cases.

    Conclusions:

    • Pasteurella pseudotuberculosis infection is not uncommon in humans and is a cause of mesenteric lymphadenitis.
    • Agglutinin testing can aid in diagnosing P. pseudotuberculosis infections, especially when symptoms overlap with appendicitis.
    • Further investigation into P. pseudotuberculosis as a cause of gastrointestinal illness is warranted.
    Keywords:
    APPENDICITISMESENTERIC LYMPHADENITISPASTEURELLA

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