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Protein tyrosine kinases belonging to the src family

K Toyoshima1, Y Yamanashi, K Inoue

  • 1Research Institute for Microbial Diseases, Osaka University, Suita, Japan.

Ciba Foundation Symposium
|January 1, 1992
PubMed

Insights

The Src family of protein tyrosine kinases are involved in cell signaling and oncogenic activation. These kinases associate with cell surface molecules, mediating extracellular signals and influencing cell differentiation.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Nine highly similar non-receptor protein tyrosine kinases constitute the Src family.
  • These kinases share common oncogenic activation sites and are linked to cell surface molecules.

Purpose of the Study:

  • To explore the association of Src family kinases with cell surface molecules.
  • To investigate their role in mediating extracellular signals via tyrosine kinase activity.
  • To discuss the functions of specific Src family members (lck, fyn, lyn, fgr) in lymphocytes and monocytes.

Main Methods:

  • Analysis of primary structures and functional domains of Src family kinases.
  • Review of recent findings on kinase association with cell surface molecules.
  • Discussion of gene products' functions based on existing literature.

Main Results:

  • Src family kinases mediate extracellular signals through tyrosine kinase activation.
  • These kinases appear to influence differentiated cell phenotypes more than hematopoietic cell proliferation.

Conclusions:

  • Src family kinases play a crucial role in signal transduction pathways.
  • Their involvement in cell differentiation and potential oncogenic activation warrants further investigation, particularly in immune cells like lymphocytes and monocytes.

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