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Milker's nodules: isolation of a poxvirus from a human case

A E FRIEDMAN-KIEN, W P ROWE, W G BANFIELD

    Science (New York, N.Y.)
    |June 21, 1963
    PubMed

    Insights

    Researchers isolated a pox virus from milker's nodules using bovine cell cultures. This virus differs significantly from vaccinia virus, suggesting it causes milker's nodule syndrome.

    Area of Science:

    • Virology
    • Dermatology
    • Infectious Diseases

    Background:

    • Milker's nodules is a benign, self-limiting skin condition caused by parapoxvirus.
    • The specific viral agent responsible for milker's nodules has been historically challenging to isolate and characterize.

    Purpose of the Study:

    • To isolate and identify the viral agent responsible for milker's nodules.
    • To differentiate the isolated virus from known poxviruses, particularly vaccinia virus.

    Main Methods:

    • Isolation of a virus from patient lesion material.
    • Cultivation of the virus in bovine cell tissue cultures.
    • Biologic and serologic characterization of the isolated virus.

    Main Results:

    • A pox group virus was successfully isolated from a milker's nodule lesion.
    • The isolated virus demonstrated significant biologic and serologic distinctions compared to vaccinia virus.
    • These findings support the virus's role as the causative agent.

    Conclusions:

    • The isolated poxvirus is likely the etiologic agent of milker's nodule syndrome.
    • The distinct characteristics of this virus warrant further investigation and differentiation from other poxviruses.
    Keywords:
    POXVIRUS INFECTIONS

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