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Mechanisms for postprandial release of motilin in humans
M Boivin1, M Bradette, M C Raymond
1Centre de recherche clinique André-Viallet, Hôpital Saint-Luc, University of Montreal, Quebec, Canada.
Abstract:
Plasma concentrations of motilin rise in the first 30 min following the ingestion of a meal in man. To elucidate the mechanisms of this postprandial motilin release, we verified the effect of cerebral stimulation and of gastric distension, both events normally occurring in the early postprandial period, on plasma motilin concentrations. Cerebral stimulation was induced by modified sham feeding (MSF) and gastric distension was done by inflating (with 0, 60, 240, or 480 cc of air) a latex balloon positioned in the gastric fundus. The experiments were performed in healthy volunteers where antroduodenal contractile activity was continuously recorded and where plasma motilin was measured each 10 min. The stimuli were administered 30 min after a phase III of the migrating motor complex (MMC) was seen migrating from the antrum to the duodenum. The interval period between two successive spontaneous peak increases in plasma motilin was estimated at 113.7 +/- 8.5 min in 24 historical control subjects, and it lasted 97 +/- 13 min in the five control volunteers here distended with 0 cc of air (P = NS). This interval was significantly (P < 0.05) shortened with MSF (70 +/- 6.3 min) or following distension with 60 cc (60 +/- 11.4 min), 240 cc (54 +/- 1.9 min) or 480 cc of air (45 +/- 3.2 min). During the 60-min period following the administration of the stimuli, phase IIIs were not seen in the subjects distended with 0 cc of air or in those submitted to MSF.(ABSTRACT TRUNCATED AT 250 WORDS)
Insights
Post-meal increases in plasma motilin are influenced by both modified sham feeding (MSF) and gastric distension. These stimuli significantly shorten the interval between motilin releases, suggesting a role in regulating digestive processes.
Area of Science:
- Gastroenterology
- Endocrinology
- Physiology
Background:
- Plasma concentrations of motilin increase post-meal in humans.
- Understanding the mechanisms of postprandial motilin release is crucial for digestive health.
- Cerebral stimulation and gastric distension are key early postprandial events.
Purpose of the Study:
- To investigate the effects of cerebral stimulation and gastric distension on plasma motilin concentrations.
- To elucidate the mechanisms underlying postprandial motilin release.
Main Methods:
- Healthy volunteers underwent modified sham feeding (MSF) and gastric distension with varying air volumes (0, 60, 240, 480 cc).
- Antroduodenal contractile activity and plasma motilin levels were continuously monitored.
- Stimuli were applied 30 minutes after a phase III of the migrating motor complex (MMC).
Main Results:
- The interval between spontaneous plasma motilin peaks was significantly shortened by MSF and gastric distension (60, 240, 480 cc).
- The control group (0 cc distension) showed no significant change in the motilin peak interval.
- Phase IIIs of the MMC were not observed during the 60-minute post-stimulus period in the MSF or 0 cc distension groups.
Conclusions:
- Both modified sham feeding and gastric distension play a significant role in stimulating postprandial motilin release.
- These findings suggest that sensory input from the gut and brain influences motilin secretion.
- The study provides insights into the regulation of gastrointestinal motility and hormone release.