[Prognostic significance of DNA content in transitional cell carcinoma of the urinary bladder]

The cellular DNA content in paraffin-embedded specimens of recurrent transitional cell carcinoma of the urinary bladder were analyzed by quantitative image analysis in 48 and flow cytometry techniques in 44 cases. The results showed a positive correlation of cellular ploidy with malignant proliferation of the tumors. The aneuploidy was increased in cases of higher clinical stages and histological grades. The prognosis of patients with diploid cells was better than those with aneuploidy, while patients with aneuploidy and higher grading showed very poor prognosis. The recurrence rate of diploid tumors was considerably lower than that of aneuploid tumors. The results indicate that such a correlation might be of clinical significance in prognosis and predicting and controlling recurrence of tumors.