[Clinical multivariate statistical analysis of nephrotoxicity induced by cisplatin]

Nephrotoxicity was studied in 47 patients who received combined chemotherapy with cisplatin (DDP, 50-100 mg/m2) as the chief agent. The treatment was given every 3-4 weeks with vigorous hydration and forced diuresis. The renal tubular toxicity was evaluated by urinary beta 2 microglobulin (beta 2-MG). It was found that the nephrotoxicity secondary to DDP was dose-dependent. Hypertonic saline was able to decrease the renal damage without any significant difference among the first, second and third course. The nephrotoxicity of DDP administered in one day was more severe than that given in two days. beta 2-MG was a good parameter of DDP nephrotoxicity. By multivariate statistical analysis, metoclopramid and chlorpromazine were found to alleviate DDP nephrotoxicity. Classification, examination and management of DDP nephrotoxicity is proposed.