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Related Experiment Videos

Two different low birth weight formulae compared.

S A Spencer1, S McKenna, J Stammers

  • 1North Staffordshire Maternity Hospital, Harpfields, Stoke-on-Trent, UK.

Early Human Development
|August 1, 1992
PubMed
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Two preterm infant formulas, Prematil and Osterprem, were compared for low birth weight infants. Osterprem, with higher fat content, led to increased energy intake but similar weight gain and poorer fat absorption compared to Prematil.

Area of Science:

  • Neonatal Nutrition
  • Pediatric Gastroenterology
  • Infant Formula Composition

Background:

  • Preterm infants require specialized nutrition for optimal growth and development.
  • Commercially available infant formulas vary in composition, potentially impacting tolerance and nutrient absorption.
  • Understanding the effects of different formula compositions is crucial for clinical practice.

Purpose of the Study:

  • To compare the clinical performance of two low birth weight formulas: Prematil and Osterprem.
  • To evaluate the impact of compositional differences, specifically fat content and medium-chain triglycerides (MCTs), on preterm infants.
  • To assess tolerance, stool characteristics, fat balance, and weight gain in response to the two formulas.

Main Methods:

  • A randomized controlled study involving preterm infants with birth weights under 1500 g.

Related Experiment Videos

  • Infants were assigned to receive either Prematil or Osterprem formula.
  • Data collection included clinical evaluation, energy intake, weight gain, stool frequency and consistency, and a three-day fat balance study.

    • Main Results:

    • Osterprem, containing 40% more fat and no MCTs, resulted in significantly higher mean energy intake (3442 kJ/kg/week) versus Prematil (3127 kJ/kg/week).
    • Despite higher energy intake, mean weight gain was not significantly different between the groups (123 g/kg/week for Osterprem vs. 112 g/kg/week for Prematil).
    • Osterprem was associated with increased stool frequency (20.5 stools/week vs. 14.5 stools/week), firmer stools, higher fat output (2.3 g/kg/day vs. 0.9 g/kg/day), and lower fat absorption (71.6% vs. 83.5%).

    Conclusions:

    • Both Prematil and Osterprem are well-tolerated in preterm infants.
    • The higher fat content in Osterprem, lacking MCTs, leads to reduced fat absorption and altered stool characteristics, without improving weight gain compared to Prematil.
    • Fat absorption is inversely related to the chain length of unsaturated fatty acids, a factor influenced by formula composition.