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Updated: Sep 16, 2026

Tibial Nerve Transection - A Standardized Model for Denervation-induced Skeletal Muscle Atrophy in Mice
Published on: November 3, 2013
The effect of denervation upon the functional properties of myosin and its fragments
Abstract:
A study has been made of some structural and enzymatic properties of myosin and its fragments from denervated white muscles of rabbit in the course of atrophy using different methods: UV-luminiscence, flow birefringence, electromicroscopy, viscosimetry and enzymatic measurements. All the studied parameters had a tendency to decrease; at prolonged observation some properties were partially restored. Considerable changes of structural properties of LMM were revealed: the ability of LMM from denervated muscle to form high-ordered structures which is characteristic of LMM from normal muscle decreased considerably.
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