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Published on: May 26, 2015
Prognosis of ventricular fibrillation in hospital
G V Jensen1, C Torp-Pedersen, L Køber
1Department of Cardiology, Glostrup County Hospital, Copenhagen, Denmark.
Insights
Patients with in-hospital ventricular fibrillation (VF) and known ischemic heart disease (IHD) but without acute myocardial infarction (AMI) face poor survival. These individuals require thorough cardiac evaluation due to high mortality risks.
Area of Science:
- Cardiology
- Internal Medicine
- Critical Care Medicine
Background:
- In-hospital ventricular fibrillation (VF) is a critical event impacting patient outcomes.
- Understanding the prognosis of VF based on underlying cardiac conditions is essential for clinical management.
Purpose of the Study:
- To evaluate the in-hospital and long-term prognosis of patients experiencing in-hospital VF.
- To compare outcomes among patients with acute myocardial infarction (MI), ischemic heart disease (IHD) without MI, and no signs of IHD.
Main Methods:
- Retrospective analysis of 520 patients with in-hospital VF.
- Statistical analysis including logistic regression and proportional hazard models.
- Categorization of patients based on the presence of MI, IHD without MI, or no IHD.
Main Results:
- In-hospital mortality was 51% for MI, 52% for IHD without MI, and 27% for no IHD.
- Heart failure and cardiogenic shock were significant risk factors for in-hospital death in IHD patients.
- Five-year survival rates varied: 51% (MI), 25% (IHD without MI), 54% (no IHD). MI was associated with reduced long-term mortality risk (RR=0.58) in IHD patients.
Conclusions:
- Patients with known IHD suffering in-hospital VF without AMI have a very poor short- and long-term prognosis.
- These high-risk patients necessitate comprehensive cardiac examinations for timely intervention.
Abstract:
In a retrospective study of 520 patients with in-hospital ventricular fibrillation 421 (81%) had acute myocardial infarction (MI), 66 (13%) had ischaemic heart disease (IHD) without MI, 33 (6%) had no signs of IHD. The in-hospital mortality of these three groups was 51%, 52%, and 27%, respectively (P = 0.01). Logistic regression analysis demonstrated that heart failure and cardiogenic shock were significant risk factors for in-hospital death among patients with IHD. Among discharged patients 1 and 5 years survival was 78% and 51% for patients with MI, 63% and 25% for patients with IHD, 67% and 54% for patients without IHD. A proportional hazard model demonstrated old age, heart failure and cardiogenic shock as risk factors for long-term prognosis, while MI was associated with a reduced relative risk ratio = 0.58 of long-term mortality among patients with IHD. In conclusion, patients with known IHD suffering in-hospital VF without AMI have a very poor short- and long-term prognosis. These patients need extensive cardiac examination.
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