Related Experiment Videos
The 26 S proteasome is activated at two points in the ascidian cell cycle
H Kawahara1, H Sawada, H Yokosawa
1Department of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo Japan.
FEBS Letters
|September 28, 1992
Abstract:
The proteasome undergoes cell cycle-dependent changes in its subcellular distribution during ascidian embryonic development [(1992) Dev. Biol. 151, 27-33]. In this study, we demonstrate that the 26 S proteasome is markedly activated in both prophase and metaphase of the mitotic cell cycle in the ascidian embryos in comparison with the case of the 20 S proteasome. These results suggest that the 26 S proteasome is activated and participates in proteolysis at the restricted stages of the cell cycle.