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A comparison of peroxidase and cytochrome P-450
1Department of Biochemistry, University of Bristol, School of Medical Sciences, U.K.
Biochemical Society Transactions
|May 1, 1992
Abstract:
A peroxidase has 1-electron oxidation as its characteristic activity, while that of cytochrome P-450 is hydroxylation. Both catalytic cycles involve similar high valency states of iron. However, a peroxidase can only accept electrons at the haem edge, while the substrate for cytochrome P-450 is bound in a precise orientation before the active state is created.