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Lp(a) concentrations in NIDDM.

S M Haffner1, P A Morales, M P Stern

  • 1Department of Medicine, University of Texas Health Science Center, San Antonio 78284-7873.

Diabetes
|October 1, 1992
PubMed
Summary
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Non-insulin-dependent diabetes mellitus (NIDDM) patients do not show increased levels of lipoprotein(a) [Lp(a)], a key marker for cardiovascular disease risk. This finding suggests Lp(a) does not explain the elevated heart disease risk in NIDDM.

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Lipidology

Background:

  • Non-insulin-dependent diabetes mellitus (NIDDM) is associated with a 2- to 4-fold increased risk of coronary heart disease (CHD).
  • Standard risk factors only partially explain this elevated CHD risk in NIDDM patients.

Purpose of the Study:

  • To compare plasma lipoprotein(a) [Lp(a)] concentrations in NIDDM patients versus nondiabetic individuals.
  • To investigate the relationship between Lp(a) levels and diabetes duration, glycemia, and lipid profiles.

Main Methods:

  • A population-based study (San Antonio Heart Study) involving 260 NIDDM patients and 336 nondiabetic subjects.
  • Plasma Lp(a) concentrations were measured using a monoclonal anti-Lp(a) antibody.

Main Results:

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  • No significant difference in Lp(a) concentrations was observed between NIDDM patients and nondiabetic subjects in both men and women.
  • Lp(a) levels were not significantly related to diabetes duration or fasting glycemia.
  • Lp(a) levels were significantly higher in individuals with elevated total and LDL cholesterol.

Conclusions:

  • In a large population-based study, Lp(a) levels are not elevated in NIDDM patients.
  • Lp(a) does not appear to be the primary factor contributing to the increased CHD risk observed in NIDDM.
  • Further research is needed to elucidate the specific mechanisms underlying the heightened cardiovascular risk in diabetic populations.