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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
[Premature membrane rupture: morbidity-mortality in pregnancies under 36 weeks]
J M Escobedo Lobaton1, E Benavides Covarrubias, L Benavides de Anda
1Hospital, Clínica y Maternidad Conchita, A.C. División de Gineco-Obstetricia, Monterrey, Nuevo León, México.
Ginecologia Y Obstetricia De Mexico
|September 1, 1992
Summary
Premature rupture of membranes (PROM) affects 1.3% of total births. In pregnancies under 36 weeks, PROM incidence is 21.5%, with significant neonatal mortality and morbidity observed.
Area of Science:
- Obstetrics
- Neonatal Medicine
- Perinatology
Background:
- Premature rupture of membranes (PROM) is a critical obstetric complication.
- Early-onset PROM, particularly before 36 weeks gestation, poses significant risks to both mother and neonate.
- Understanding the incidence and outcomes of PROM is crucial for improving perinatal care.
Purpose of the Study:
- To determine the incidence of PROM in pregnancies at or before 36 weeks gestation.
- To analyze the associated infectious mortality, maternal mortality, cesarean section rates, and neonatal outcomes.
- To evaluate short-term and two-year global mortality in affected neonates.
Main Methods:
- Retrospective analysis of birth data.
- Calculation of PROM incidence based on total births and gestational age subgroups (<36 weeks, <34 weeks).
- Assessment of maternal and neonatal mortality, infectious morbidity, and cesarean section rates.
Main Results:
- PROM incidence was 1.3% of total births (3,796).
- In pregnancies <36 weeks, PROM incidence was 21.5% (49 cases); in <34 weeks, it was 0.47% (17 cases).
- Infectious mortality was 2.2%, with no maternal mortality. Cesarean section rate was 43%. Neonatal infectious morbidity was 16.3%, neonatal mortality was 13.0% (4/30), and global mortality at two years was 17.0% (5/30).
Conclusions:
- PROM before 36 weeks gestation is associated with substantial neonatal morbidity and mortality.
- While maternal mortality was absent, the high rates of cesarean delivery and neonatal complications underscore the severity of early PROM.
- Further research into preventative strategies and improved neonatal care for PROM is warranted.
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