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Successful use of high-dose cyclophosphamide in a child with severe autoimmune hemolytic anemia
R Panceri1, D Fraschini, G Tornotti
1Divisione di Ematologia Pediatrica, Università di Milano, Monza, Italy.
Haematologica
|January 1, 1992
Abstract:
We report the case of a five-month-old boy with a life-threatening autoimmune hemolytic anemia that was unresponsive to conventional therapy with steroids, high-dose immunoglobulin, azathioprine and splenectomy. Despite these therapies, the patient's condition worsened, requiring 2-3 blood transfusions/day, since the hemoglobin level was constantly below 4 g/dl. We eventually increased immunosuppression by giving high-dose cyclophosphamide and the child showed a striking, sudden improvement, followed by complete recovery. No major long-term complications were observed.