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How blood viscosity influences changes in circulation during pregnancy?
K Sakai1, H Maeda, K Tsukimori
1Department of Gynecology and Obstetrics, Faculty of Medicine, Kyushu University, Fukuoka.
Fukuoka Igaku Zasshi = Hukuoka Acta Medica
|August 1, 1992
Summary
During normal pregnancy, whole blood viscosity significantly decreases in the second trimester, correlating with hematocrit changes. Plasma viscosity remained stable, suggesting blood viscosity changes aid in reducing peripheral resistance.
Area of Science:
- Obstetrics and Gynecology
- Physiology
- Hemodynamics
Background:
- Pregnancy involves significant physiological adaptations.
- Understanding hemorheological changes during pregnancy is crucial for maternal and fetal health.
Purpose of the Study:
- To investigate changes in whole blood viscosity and plasma viscosity throughout normal pregnancy.
- To explore correlations between viscosity, hematocrit, and plasma fibrinogen levels.
Main Methods:
- Studied 15 non-pregnant women and 120 pregnant women (8-39 weeks gestation).
- Measured whole blood viscosity and plasma viscosity.
- Analyzed correlations with hematocrit and plasma fibrinogen.
Main Results:
- Whole blood viscosity was significantly lower between 20-31 weeks gestation.
- A positive correlation was observed between whole blood viscosity and hematocrit.
- Plasma viscosity showed no significant changes during pregnancy and no correlation with fibrinogen.
Conclusions:
- Decreased whole blood viscosity in the second trimester, linked to packed-cell volume, likely contributes to reduced peripheral resistance.
- These hemorheological adjustments may be vital for managing circulatory demands during pregnancy.