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SMS 201-995 and thyroid function in acromegaly: acute, intermediate and long-term effects.
S E Christensen1, J Weeke, A Kaal
1Medical Department M (Endocrinology and Diabetes), Aarhus Kommunehospital, Denmark.
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|May 1, 1992
Summary
SMS 201-995 (octreotide) has minimal impact on thyroid function. Acute treatment transiently suppresses TSH response, while long-term use shows only a clinically irrelevant increase in TSH.
Area of Science:
- Endocrinology
- Pharmacology
Background:
- Thyroid function is crucial for metabolic regulation.
- SMS 201-995 (octreotide) is a somatostatin analog used in conditions like acromegaly.
- Understanding octreotide's effects on the thyroid is important for patient management.
Purpose of the Study:
- To investigate the acute, intermediate, and long-term effects of SMS 201-995 (octreotide) on thyroid function.
- To assess the impact of octreotide on thyroid-stimulating hormone (TSH) and thyroid hormone levels.
Main Methods:
- TRH-stimulation tests were performed in healthy volunteers.
- Continuous subcutaneous infusion (CSI) of SMS 201-995 was administered to acromegalic patients.
- Diurnal hormone profiles were analyzed over a 30-month period.
Main Results:
- SMS 201-995 acutely reduced TSH response by over 50% in healthy volunteers.
- Intermediate treatment in acromegalic patients showed a transient decrease in total triiodothyronine (TT3) and an increase in TSH.
- Long-term SMS 201-995 administration resulted in a barely significant, clinically irrelevant increase in TSH.
Conclusions:
- SMS 201-995 has a transient inhibitory effect on thyroid function, particularly on TSH response.
- Long-term octreotide treatment does not significantly alter thyroid function.
- The observed changes in thyroid function are clinically insignificant.