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Concurrent salmonellosis and histoplasmosis in AIDS: an unusual co-existence in Britain
S Crowley1, R J Coker, S M Murphy
1Department of Genitourinary Medicine, Patrick Clements Clinic, Central Middlesex Hospital, London, UK.
Genitourinary Medicine
|August 1, 1992
Abstract:
A patient is described with systemic salmonellosis which was unresponsive to therapy. Histoplasma capsulatum was isolated after death and we suggest that dysfunction of the reticuloendothelial system by H. capsulatum may have altered the prognosis.
Insights
Systemic salmonellosis unresponsive to treatment suggests a potential secondary infection. Histoplasma capsulatum identified post-mortem indicates reticuloendothelial system dysfunction may have impacted the patient's outcome.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Immunology
Background:
- Systemic salmonellosis is a severe bacterial infection requiring prompt antimicrobial therapy.
- Reticuloendothelial system (RES) dysfunction can impair host defense mechanisms.
- Histoplasma capsulatum is an opportunistic fungal pathogen.
Observation:
- A patient presented with systemic salmonellosis that did not respond to standard treatment.
- The patient's condition deteriorated despite therapeutic interventions.
- Post-mortem examination revealed the presence of Histoplasma capsulatum.
Findings:
- Histoplasma capsulatum was isolated from the patient after death.
- The fungal infection was not initially suspected or diagnosed during the patient's illness.
- The presence of H. capsulatum suggests a potential role in the patient's unresponsiveness to salmonellosis therapy.
Implications:
- Fungal infections, such as histoplasmosis, can complicate bacterial infections like salmonellosis.
- RES dysfunction caused by H. capsulatum may compromise the immune response to other pathogens.
- This case highlights the importance of considering opportunistic infections in immunocompromised or critically ill patients.
- Altered prognosis in severe salmonellosis could be linked to concurrent opportunistic fungal infections impacting immune function.