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[Antiphospholipid syndrome].

M Steffen1

  • 1Medizinische Kernklinik, Universitäts-Krankenhaus Eppendorf, Hamburg, Federal Republic of Germany.

Immunitat Und Infektion
|August 1, 1992
PubMed
Summary
This summary is machine-generated.

Antiphospholipid antibodies, including lupus anticoagulant and anticardiolipin antibodies, are linked to blood clots. Antiphospholipid syndrome can occur with autoimmune diseases like lupus or independently.

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Area of Science:

  • Immunology
  • Rheumatology
  • Hematology

Context:

  • Autoantibodies against phospholipids are implicated in thrombotic events.
  • Antiphospholipid syndrome (APS) is a recognized clinical entity.
  • APS is frequently associated with systemic lupus erythematosus (SLE) and other autoimmune conditions.

Purpose:

  • To summarize the association between antiphospholipid antibodies and thrombosis.
  • To describe the antiphospholipid syndrome (APS).
  • To highlight the occurrence of APS in both secondary and primary forms.

Summary:

  • Antibodies targeting phospholipids, such as lupus anticoagulant and anticardiolipin antibodies, show a strong correlation with both venous and arterial thrombosis.
  • Antiphospholipid syndrome is defined by the presence of these autoantibodies and thrombotic events.

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  • While often seen in patients with systemic lupus erythematosus or related autoimmune disorders, APS can also manifest primarily.

    • Impact:

    • Understanding the link between antiphospholipid antibodies and thrombosis is crucial for diagnosis and management.
    • Recognition of APS, whether secondary to other autoimmune diseases or primary, aids in risk stratification for thrombotic events.
    • This knowledge supports the development of targeted therapies and preventative strategies for patients at risk of APS-related complications.