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Multiply resistant Haemophilus influenzae type b causing meningitis.

S K Amarnath1, R Kanungo, R S Rao

  • 1Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education & Research, Pondicherry.

The Indian Journal of Medical Research
|July 1, 1992
PubMed
Summary

Two multidrug-resistant *Haemophilus influenzae* strains causing meningitis were identified. Cephalosporins and gentamicin show effectiveness against these resistant bacteria, offering treatment options for meningitis patients.

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Area of Science:

  • Clinical microbiology
  • Infectious diseases
  • Antimicrobial resistance

Background:

  • Meningitis remains a significant global health concern, often caused by *Haemophilus influenzae*.
  • The emergence of multidrug-resistant bacterial strains poses a substantial challenge to effective meningitis treatment.
  • Understanding resistance patterns is crucial for guiding empirical antibiotic therapy.

Purpose of the Study:

  • To report the isolation of multidrug-resistant *Haemophilus influenzae* from meningitis patients.
  • To evaluate the susceptibility of these resistant strains to various antibiotics.
  • To identify effective antibiotic agents for treating meningitis caused by resistant strains.

Main Methods:

  • Isolation and identification of *Haemophilus influenzae* strains from patient samples.

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  • Antimicrobial susceptibility testing, including determination of Minimum Inhibitory Concentrations (MICs).
  • Phenotypic detection of beta-lactamase production.

    • Main Results:

    • Two multidrug-resistant *Haemophilus influenzae* strains were isolated from meningitis patients.
    • These resistant isolates exhibited higher MICs compared to susceptible strains for commonly used meningitis drugs.
    • Beta-lactamase production was confirmed in the resistant isolates.
    • Cephalosporins and gentamicin demonstrated efficacy against the resistant strains.
    • Resistance was observed against ampicillin, chloramphenicol, cloxacillin, cotrimoxazole, tetracycline, penicillin, and erythromycin.

    Conclusions:

    • The presence of multidrug-resistant *Haemophilus influenzae* is a significant concern for meningitis treatment.
    • Cephalosporins and gentamicin are effective therapeutic options against these resistant strains.
    • Continuous monitoring of antimicrobial resistance patterns is essential for optimizing meningitis management.