Related Experiment Videos
Hemostatic profile in neonatal septicemia.
V Alamelu1, A K Dutta, S Narayan
1Department of Pediatrics, Kalawati Saran Children's Hospital, New Delhi.
Indian Journal of Pediatrics
|March 1, 1992
Summary
Neonatal septicemia frequently causes hemostatic defects, impacting coagulation and platelet function in 96% of affected infants. These blood clotting issues occur even without visible bleeding, highlighting the systemic effects of infection.
Area of Science:
- Neonatal Medicine
- Hematology
- Infectious Diseases
Background:
- Neonatal septicemia is a serious condition with significant morbidity.
- Hemostatic system alterations are suspected in septic neonates but require detailed investigation.
Purpose of the Study:
- To comprehensively evaluate the hemostatic profile in neonates with proven septicemia.
- To compare coagulation and platelet function in septic neonates versus healthy controls.
Main Methods:
- Studied 25 full-term neonates with blood culture-proven septicemia.
- Included 25 matched healthy neonates as controls.
- Performed detailed coagulation tests and platelet function studies using standard techniques.
Main Results:
- Hemostatic defects were observed in 96% of septicemic neonates, compared to 0% in controls.
- Coagulation tests were abnormal in 80% and platelet function tests in 92% of septic neonates.
- Significant derangements in hemostatic tests were noted in septicemic neonates.
Conclusions:
- Neonatal septicemia is strongly associated with widespread hemostatic defects.
- These defects affect both coagulation and platelet function, irrespective of clinical bleeding.
- Early assessment of hemostasis is crucial in neonates with suspected septicemia.