Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clomiphene's effect on endometrium in infertility.

J A Benda1

  • 1Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City 52242.

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
|October 1, 1992
PubMed
Summary

Clomiphene citrate use in infertility patients alters the secretory-phase endometrium, creating a distinct histological pattern. These changes suggest a potential hypoestrogenic effect, impacting endometrial receptivity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human immunodeficiency virus testing in patients with invasive cervical carcinoma: a prospective trial of the gynecologic oncology group.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2006
Same author

Pathology of smooth muscle tumors of the uterine corpus.

Clinical obstetrics and gynecology·2001
Same author

Promotion of neovascularization around hollow fiber bioartificial organs using biologically active substances.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·1999
Same author

Primary ovarian sarcoma: analysis of prognostic variables and the role of surgical cytoreduction.

Cancer·1998
Same author

Nasopharyngeal teratoma. Report of a case with prenatal diagnosis and postnatal management.

The Journal of reproductive medicine·1997
Same author

Neurotropic desmoplastic melanoma of the vulva.

Gynecologic oncology·1997

Area of Science:

  • Reproductive Endocrinology
  • Gynecologic Pathology
  • Infertility Research

Background:

  • Clomiphene citrate is a widely used medication for ovulation induction in infertility treatment.
  • Endometrial histology provides crucial insights into reproductive health and treatment efficacy.
  • Understanding treatment-induced endometrial changes is vital for optimizing fertility outcomes.

Purpose of the Study:

  • To identify and characterize the histological features of the secretory-phase endometrium in patients treated with clomiphene citrate.
  • To compare endometrial biopsies from clomiphene-treated patients with normal endometrial histology.
  • To evaluate the potential endocrine effects underlying the observed histological changes.

Main Methods:

  • Retrospective review of 710 endometrial biopsies from 566 infertility patients.

Related Experiment Videos

  • Analysis included 108 biopsies from 79 patients receiving clomiphene citrate.
  • Histological assessment focused on glandular morphology, gland-to-stroma ratio, vacuolization, secretion, and stromal changes.

    • Main Results:

    • Clomiphene-treated patients exhibited straight, narrow, and less tortuous endometrial glands compared to controls.
    • A decreased gland-to-stroma ratio was observed.
    • Key findings included crisp subnuclear vacuoles, distinct luminal borders, scant and inspissated secretions, low cuboidal epithelium, and altered stromal predecidualization, consistent with a hypoestrogenic effect.

    Conclusions:

    • The secretory-phase endometrium in clomiphene-treated patients displays a distinctive histological character.
    • Observed endometrial features suggest a hypoestrogenic effect, potentially influencing endometrial receptivity.
    • Further research may elucidate the clinical implications of these histological findings on fertility.