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Lymphocyte migration through extracellular matrix.

S Ratner1

  • 1Breast Cancer Program, Meyer L. Prentis Comprehensive Cancer Center of Metropolitan Detroit, Mich.

Invasion & Metastasis
|January 1, 1992
PubMed
Summary
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Lymphocyte migration through the extracellular matrix (ECM) is crucial for immune responses. Activated lymphocytes exhibit enhanced motility via specific receptors and molecular pathways, though in vivo mechanisms require further study.

Area of Science:

  • Immunology
  • Cell Biology
  • Biomathematics

Background:

  • Lymphocyte movement through the extracellular matrix (ECM) is vital for immune cell trafficking and inflammatory site infiltration.
  • Understanding lymphocyte migration mechanisms is essential for comprehending immune responses and developing therapeutic strategies.

Purpose of the Study:

  • To review current knowledge on the mechanisms governing lymphocyte migration through the ECM.
  • To identify key factors and molecular events regulating lymphocyte motility and infiltration.

Main Methods:

  • The review synthesizes findings from in vitro studies using models of basement membranes, interstitial stroma, and their components.
  • Analysis of data on lymphocyte responses to antigens, mitogens, and lymphokines.

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Main Results:

  • Lymphocyte motility is highly plastic, increasing significantly upon activation.
  • Activation involves G0/G1 transition, protein kinase C signaling, and potentially long-lasting changes in motility.
  • Receptors for ECM components (fibronectin, laminins, collagens) and enzymes like heparanases are implicated in lymphocyte migration.

Conclusions:

  • Lymphocyte migration through ECM is a complex process regulated by activation state and molecular interactions.
  • While in vitro models provide insights, significant gaps remain in understanding in vivo infiltration and molecular regulation.