Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

T1 in subacute and chronic brain infarctions. Time-dependent development.

N Lundbom1, K Katevuo, M Komu

  • 1Department of Diagnostic Radiology, University of Turku, Finland.

Investigative Radiology
|September 1, 1992
PubMed
Summary

This study tracked T1 changes in brain tissue after stroke. Recent infarcts show distinct T1 behavior, differing from older lesions and affecting the contralateral hemisphere.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Treatment response of colorectal cancer liver metastases to neoadjuvant or conversion therapy: a prospective multicentre follow-up study using MRI, diffusion-weighted imaging and <sup>1</sup>H-MR spectroscopy compared with histology (subgroup in the RAXO trial).

ESMO open·2021
Same author

Apolipoprotein B48 metabolism in chylomicrons and very low-density lipoproteins and its role in triglyceride transport in normo- and hypertriglyceridemic human subjects.

Journal of internal medicine·2019
Same author

Prosthetic Rehabilitation with Implant-Supported Mandibular Overdenture after Partial Glossectomy and Radiation Therapy: A Case Report.

The European journal of prosthodontics and restorative dentistry·2018
Same author

Metabolic syndrome associates with left atrial dysfunction.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2018
Same author

Physical activity, cardiorespiratory fitness, and metabolic outcomes in monozygotic twin pairs discordant for body mass index.

Scandinavian journal of medicine & science in sports·2017
Same author

Adverse effects of fructose on cardiometabolic risk factors and hepatic lipid metabolism in subjects with abdominal obesity.

Journal of internal medicine·2017

Area of Science:

  • Neuroimaging
  • Stroke research
  • Biomedical engineering

Background:

  • Stroke is a leading cause of long-term disability.
  • Understanding the temporal evolution of brain tissue changes post-stroke is crucial for diagnosis and treatment.
  • Magnetic Resonance Imaging (MRI) provides valuable insights into tissue properties.

Purpose of the Study:

  • To investigate the time-dependent changes in T1 relaxation times within brain infarcts and the contralateral hemisphere.
  • To characterize the subacute and early chronic stages of stroke using T1 mapping.
  • To differentiate recent infarcts from older, gliotic lesions based on T1 behavior.

Main Methods:

  • T1 relaxation times were measured using MRI in 29 patients with varying infarct locations and ages.

Related Experiment Videos

  • Consecutive MRI studies were performed on 11 patients within the first 5 weeks post-stroke.
  • Histographic analysis of T1 maps was employed to analyze T1 distribution in infarctions.

    • Main Results:

    • T1 was significantly longer in infarcted gray matter compared to white matter within the first 2 months post-stroke (P = .002).
    • A linear prolongation of T1 was observed in both gray and white matter infarcts.
    • Tissue breakdown products contributed to a T1 component identifiable for up to 5 weeks.
    • A transient T1 lengthening in the contralateral hemisphere peaked at 3 weeks post-stroke.

    Conclusions:

    • The observed T1 characteristics in recent infarcts distinguish them from chronic, gliotic lesions.
    • The contralateral hemisphere T1 lengthening suggests remote hemodynamic and metabolic alterations following brain infarction.
    • T1 mapping offers a valuable tool for assessing the temporal dynamics of stroke-related brain changes.