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Comparative in-vitro activity of RP 59500 against clinical bacterial isolates
1Department of Microbiology, Kitasato University School of Medicine, Japan.
The Journal of Antimicrobial Chemotherapy
|July 1, 1992
Abstract:
The activity of RP 59500 against Gram-positive cocci was determined by an agar dilution method and compared with that of erythromycin, cefotaxime and ampicillin. Of the 344 clinical isolates tested, none was resistant to RP 59500; this compound was active both against methicillin-resistant Staphylococcus aureus and against macrolide-resistant Gram-positive cocci. The bactericidal activity of RP 59500 was confirmed by killing curve determinations.