Related Experiment Videos
High-performance liquid chromatographic method for the determination of alprazolam in plasma using the
1Lehrstuhl für Innere Medizin, Gerontologie, Universität Erlangen-Nürnberg, Germany.
Journal of Chromatography
|July 24, 1992
Abstract:
A reversed-phase high-performance liquid chromatographic method is described for the quantitative determination of alprazolam in the plasma of geriatric patients in the presence of 4-hydroxyalprazolam, alpha-hydroxyalprazolam, bromazepam, oxazepam, lorazepam, clobazam, desmethylclobazam, diazepam and desmethyldiazepam. The procedure is based on the enrichment of alprazolam on a PRP-1 pre-column, followed by the transfer of the compound in a forflush mode to the analytical column. Alprazolam can be quantified reliably down to a minimum concentration of 1 ng/ml of plasma.