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Epizootic diarrhea of infant mice: indentification of the etiologic agent

W R ADAMS, L M KRAFT

    Science (New York, N.Y.)
    |July 26, 1963
    PubMed

    Insights

    Epizootic diarrhea virus in infant mice causes spherical particles within intestinal cells. These particles, 65-75 µm in size, are linked to endoplasmic reticulum vesicles and are considered the disease

    Area of Science:

    • Virology
    • Cell Biology
    • Gastroenterology

    Background:

    • Epizootic diarrhea virus (EDV) is a significant pathogen affecting infant animals.
    • Understanding the viral etiology and cellular interactions is crucial for disease management.

    Purpose of the Study:

    • To characterize the morphology and cellular localization of the suspected etiologic agent of epizootic diarrhea virus in infant mice.

    Main Methods:

    • Electron microscopy was used to examine the intestinal epithelium of infected infant mice.
    • Morphological analysis focused on intracellular structures associated with the disease.

    Main Results:

    • Spherical intracellular structures, 65-75 µm in diameter, were observed in the intestinal epithelium.
    • These structures exhibited complex morphology, resembling virus particles.
    • Particles were found within or associated with endoplasmic reticulum vesicles, but not in the nucleus.

    Conclusions:

    • The observed particles are interpreted as the etiologic agent of epizootic diarrhea virus.
    • The endoplasmic reticulum appears to be involved in the replication or assembly of the virus.
    Keywords:
    ANIMALS, NEWBORNDIARRHEAMICERODENT DISEASESVIRUS DISEASES

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