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Cyclosporine therapy for psoriasis: a cell cycle-derived dosing schedule
M M Goodman1, G M White, A McCormick
1Department of Dermatology, University of California, Irvine.
Journal of the American Academy of Dermatology
|October 1, 1992
Summary
This study explored a novel 36-hour dosing schedule for cyclosporine in psoriasis treatment. While effective, the regimen did not demonstrate significant advantages over daily dosing due to side effects.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Cyclosporine is an effective psoriasis treatment but has serious side effects limiting long-term use.
- A new dosing regimen was investigated based on the psoriatic keratinocyte cell cycle.
Purpose of the Study:
- To evaluate a 36-hour weekly cyclosporine dosing schedule for psoriasis.
- To decrease side effects while maintaining treatment efficacy.
Main Methods:
- Fifteen patients received oral cyclosporine at 12-hour intervals, three times per week for 10 weeks.
- Doses started at 2.5 mg/kg/dose and increased every 2 weeks to a maximum of 10 mg/kg/dose.
Main Results:
- Average Psoriasis Area and Severity Index improvement was 61% across all patients.
- Six patients achieved >75% improvement; others showed varied responses.
- Three patients discontinued due to adverse effects; three others required dose reduction.
Conclusions:
- The 36-hour dosing regimen for cyclosporine showed effectiveness in psoriasis treatment.
- This regimen may not offer advantages over daily dosing due to its side effect profile and high dose requirements.