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Related Experiment Videos

Interactions between segmented polyurethane surfaces and the plasma protein fibrinogen.

S I Stupp, J W Kauffman, S H Carr

    Journal of Biomedical Materials Research
    |March 1, 1977
    PubMed
    Summary

    Segmented polyurethane surfaces affect fibrinogen adsorption. Higher polyether segment content on glass surfaces led to more fibrinogen adsorption compared to poly(ethylene terephthalate) surfaces.

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    Area of Science:

    • Biomaterials Science
    • Polymer Chemistry
    • Surface Science

    Background:

    • Segmented polyurethanes are widely used biomaterials.
    • Surface properties significantly influence biological interactions.
    • Understanding surface-protein interactions is crucial for blood compatibility.

    Purpose of the Study:

    • To investigate the effect of different substrates on segmented polyurethane surface composition.
    • To correlate surface composition with fibrinogen adsorption.
    • To elucidate the role of surface chemistry in blood compatibility.

    Main Methods:

    • Segmented polyurethane films were cast on poly(ethylene terephthalate) (PET) and glass substrates.
    • Surface composition was analyzed using infrared-attenuated total-reflection spectroscopy (ATR).

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  • Fibrinogen adsorption was quantified on the prepared surfaces.

    • Main Results:

    • Polyurethane surfaces cast on glass exhibited higher polyether segment content.
    • Surfaces cast on PET showed a higher relative concentration of aromatic segments.
    • Increased fibrinogen adsorption and conformational changes were observed on surfaces with higher polyether content.

    Conclusions:

    • Surface composition of segmented polyurethanes is influenced by the substrate.
    • Polyether-rich surfaces promote greater fibrinogen adsorption.
    • The presence of peptide-like bonds on aromatic segments contributes to the blood compatibility of polyurethanes.