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Published on: October 12, 2017
Lipoprotein [Lp(a)] and peripheral vascular disease
1Department of Pharmacology and Therapeutics, Trinity College Medical School, St James's Hospital, Dublin, Ireland.
Journal of Internal Medicine
|October 1, 1992
Summary
Elevated Lipoprotein(a) [Lp(a)] levels are significantly linked to peripheral vascular disease (PVD) and coronary heart disease risk. This study found higher Lp(a) concentrations in PVD patients compared to healthy controls.
Area of Science:
- Cardiovascular Medicine
- Lipidology
- Vascular Biology
Background:
- Lipoprotein(a) [Lp(a)] is an established independent risk factor for coronary heart disease.
- The association between Lp(a) and peripheral vascular disease (PVD) requires further investigation.
Purpose of the Study:
- To investigate the relationship between Lp(a) levels and peripheral vascular disease (PVD).
- To assess if Lp(a) is an independent risk factor for PVD, with or without concomitant ischaemic heart disease (IHD).
Main Methods:
- A case-control study involving 84 patients with PVD (42 with IHD) and 43 healthy controls.
- Measurement of Lp(a) concentrations in all participants.
- Multivariate logistic regression analysis adjusted for age and sex.
Main Results:
- Mean Lp(a) concentrations were significantly higher in male (nearly threefold) and female (more than twofold) PVD patients compared to controls.
- Elevated Lp(a) was observed in PVD patients regardless of concomitant IHD.
- Lp(a) was independently associated with PVD (OR=1.35, P<0.01) and IHD (OR=1.65, P<0.01) per 100 mg/L increase.
Conclusions:
- Lipoprotein(a) is an independent risk factor for peripheral vascular disease.
- Elevated Lp(a) levels are strongly associated with PVD and may contribute to the development of concomitant ischaemic heart disease.
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