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The dorsolateral prefrontal cortex, schizophrenia and PET.

K J Friston1

  • 1MRC Cyclotron Unit, Hammersmith Hospital, London, United Kingdom.

Journal of Neural Transmission. Supplementum
|January 1, 1992
PubMed
Summary

Positron emission tomography (PET) reveals regional brain abnormalities in schizophrenia. Studies show deficits in dorsolateral prefrontal cortex, aiding understanding of this complex neurological disorder.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • Central neurophysiology is measurable using Positron Emission Tomography (PET).
  • PET studies offer insights into regional brain abnormalities in schizophrenia.
  • Cross-sectional studies have identified common regional deficits in schizophrenic subjects.

Purpose of the Study:

  • To review methodological considerations and hypotheses for cross-sectional and activation studies in schizophrenia.
  • To discuss the lesion and functional anatomy models of brain function in schizophrenia.
  • To present empirical data implicating the dorsolateral prefrontal cortex in schizophrenic symptoms.

Main Methods:

  • Utilizing Positron Emission Tomography (PET) for central neurophysiology measurements.
  • Employing cross-sectional studies to identify regional deficits.
  • Implementing fast dynamic measurements of regional cerebral blood flow for activation studies.

Main Results:

  • PET measurements provide insights into regional abnormalities in schizophrenia.
  • Activation studies allow for rapid serial measurements in different brain states.
  • Empirical data implicates the dorsolateral prefrontal cortex in schizophrenic symptoms.

Conclusions:

  • PET is a valuable tool for studying neurophysiology in schizophrenia.
  • Both cross-sectional and activation studies, interpreted with methodological considerations, advance our understanding.
  • The dorsolateral prefrontal cortex is a key region implicated in the pathophysiology of schizophrenia.

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