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Related Experiment Videos

The alien hand and related signs.

R S Doody1, J Jankovic

  • 1Baylor College of Medicine, Department of Neurology, Houston, Texas 77030.

Journal of Neurology, Neurosurgery, and Psychiatry
|September 1, 1992
PubMed
Summary

Alien limb sign involves feeling a body part is foreign and acting involuntarily. This study describes seven patients with alien limb sign, exploring its causes and associated motor and behavioral symptoms.

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Area of Science:

  • Neurology
  • Neuroscience
  • Clinical Psychology

Background:

  • Alien limb sign is a complex neurological disorder characterized by a loss of ownership and voluntary control over a limb.
  • Symptoms include a feeling of foreignness, personification, and autonomous limb activity, often affecting the hand but potentially any limb.

Purpose of the Study:

  • To characterize the alien limb sign phenomenon through case studies.
  • To explore associated motor and behavioral manifestations.
  • To discuss potential etiologies and anatomical bases.

Main Methods:

  • Case series of seven patients presenting with alien limb sign.
  • Clinical assessment of motor and behavioral symptoms.
  • Review of phenomenological spectrum and diagnostic protocols.

Main Results:

  • Patients exhibited apraxia, bimanual coordination issues, and involuntary motor activities.
  • Two patients displayed self-destructive behaviors; grasp reflex was common.
  • Cortical reflex myoclonus was observed in patients with corticobasal ganglionic degeneration (CBD).

Conclusions:

  • Alien limb sign presents with a diverse range of motor and behavioral symptoms.
  • Etiologies include cerebrovascular events and neurodegenerative diseases like CBD.
  • Further research into anatomical correlates and diagnostic criteria is warranted.

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