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Related Experiment Videos

Ewing's sarcoma: experience with 12 cases.

B Zülfikar1, G Gedikoğlu

  • 1Istanbul University, Istanbul Medical School, Turkey.

Journal of Chemotherapy (Florence, Italy)
|February 1, 1992
PubMed
Summary
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Localized Ewing's sarcoma treatment in children showed high remission rates with chemotherapy and radiotherapy. However, relapses and treatment complications occurred, with better prognosis for younger patients with long bone tumors.

Area of Science:

  • Pediatric Oncology
  • Medical Research
  • Cancer Treatment

Background:

  • Ewing's sarcoma is a rare bone cancer primarily affecting children and young adults.
  • Treatment strategies have evolved, with chemotherapy and radiotherapy being cornerstone therapies.
  • Understanding prognostic factors is crucial for optimizing patient outcomes.

Purpose of the Study:

  • To evaluate the treatment outcomes of localized Ewing's sarcoma in pediatric patients.
  • To identify factors influencing prognosis and survival in this patient cohort.
  • To assess the efficacy of different chemotherapy protocols used in combination with radiotherapy.

Main Methods:

  • Retrospective analysis of 12 pediatric patients with localized Ewing's sarcoma treated between 1980-1990.

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  • Review of treatment modalities including chemotherapy (VAC, VACA, IVAD, T.9) and radiotherapy.
  • Assessment of remission rates, relapse patterns, survival, and prognostic indicators.

    • Main Results:

    • High initial remission rates (11 out of 12 patients) were achieved with combined chemotherapy and radiotherapy.
    • Seven patients relapsed, with 4 local and 3 distant metastases.
    • Factors associated with better prognosis included tumor location in long bones, smaller tumor volume (<100 ml), and younger age (<5 years).
    • No significant differences were observed among the various chemotherapy protocols used.

    Conclusions:

    • Combined chemotherapy and radiotherapy can achieve high remission rates in localized Ewing's sarcoma.
    • Relapse remains a significant challenge, necessitating continued research into improved treatment strategies.
    • Early diagnosis and treatment, particularly for younger children with favorable tumor characteristics, are associated with better outcomes.