Oxidative decarboxylation of naproxen
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F Boscá1, R Martínez-Máñez, M A Miranda
1Departamento de Química, Universidad Politécnica de Valencia, Spain.
Journal of Pharmaceutical Sciences
|May 1, 1992
Abstract:
The decarboxylation of naproxen (1H) and its salt (1-) was achieved by means of chemical [Ce(IV) or S2O8(2-)] and electrochemical oxidation. The product patterns were compatible with mechanisms involving single-electron transfer from the pi-system or the carboxylate moiety. The results are discussed in connection with the involvement of electron-transfer processes in the reported phototoxicity of naproxen.