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Fluoride concentrations in human and rat bone.

D M Eble1, T G Deaton, F C Wilson

  • 1Department of Pediatric Dentistry, School of Dentistry, University of North Carolina, Chapel Hill 27599-7455.

Journal of Public Health Dentistry
|January 11, 1992
PubMed
Summary
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Human bone fluoride levels increase with age, with higher concentrations found in trabecular bone. These findings reflect changing systemic fluoride exposure patterns in the US population.

Area of Science:

  • Biochemistry
  • Orthopedics
  • Toxicology

Background:

  • Recent data on human bone fluoride concentrations are scarce, despite changing systemic fluoride exposure patterns.
  • Understanding bone fluoride levels is crucial for assessing long-term fluoride exposure and its health implications.

Purpose of the Study:

  • To determine current fluoride concentrations in human bone.
  • To investigate the relationship between bone fluoride levels, age, and bone type.
  • To compare findings with historical data and assess implications for public health.

Main Methods:

  • Bone samples were collected from 24 human subjects undergoing orthopedic surgery.
  • Systemic fluoride exposure history was obtained for each subject.
  • Fluoride concentration in bone ash was measured using acid diffusion and ion-selective electrode methods.

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Main Results:

  • Human bone fluoride concentrations ranged from 378 to 3,708 ppm.
  • Bone fluoride levels showed a significant positive correlation with age (r = .62).
  • Trabecular bone exhibited higher fluoride concentrations than cortical bone, a finding also observed in rat models.

Conclusions:

  • Human bone fluoride levels are increasing, consistent with rising systemic fluoride exposure.
  • Age and bone type are significant factors influencing fluoride accumulation in bone.
  • The data provide valuable insights into long-term fluoride exposure in the US population.