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Renal involvement in primary antiphospholipid syndrome.
M C Amigo1, R Garcia-Torres, M Robles
1Department of Rheumatology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico.
The Journal of Rheumatology
|August 1, 1992
Summary
Primary antiphospholipid syndrome (APS) can cause significant kidney disease, characterized by hypertension, proteinuria, and renal failure. Kidney biopsies reveal thrombotic microangiopathy affecting arterioles and glomerular capillaries in affected patients.
Area of Science:
- Nephrology
- Rheumatology
- Pathology
Background:
- Primary antiphospholipid syndrome (APS) is an autoimmune disorder associated with an increased risk of thrombosis.
- Renal involvement in APS is not fully characterized, necessitating further investigation into its prevalence and pathological features.
Purpose of the Study:
- To define the renal involvement in patients diagnosed with primary antiphospholipid syndrome (APS).
- To investigate the clinical characteristics and pathological findings of kidney disease in primary APS.
Main Methods:
- Studied 20 patients with primary APS, assessing renal function and hypertension.
- Conducted kidney biopsies on patients with diagnosed renal disease.
- Histopathological analysis of kidney biopsies to identify characteristic lesions.
Main Results:
- Renal disease was identified in 25% (5 out of 20) of patients with primary APS.
- Affected patients presented with proteinuria, hypertension, and renal failure.
- Kidney biopsies showed thrombotic microangiopathy, including arteriolar and glomerular capillary thrombosis, mesangiolysis, and ischemic changes.
Conclusions:
- Primary APS is associated with a significant incidence of renal disease.
- The renal pathology in primary APS is consistent with thrombotic microangiopathy.
- Early detection and management of renal complications are crucial in patients with primary APS.