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Related Experiment Video

Updated: Jul 18, 2026

Study of Experimental Organ Donation Models for Lung Transplantation
08:56

Study of Experimental Organ Donation Models for Lung Transplantation

Published on: March 15, 2024

TOLERANCE BETWEEN HOST AND DONOR TISSUE IN BIRDS.

W S LAPP, F N JEROME, A T CRINGAN

    Science (New York, N.Y.)
    |August 30, 1963
    PubMed
    Summary

    Two methods, parabiosis and embryonic limb bud transplants, successfully induced host tolerance to donor cells in chicken embryos. The extent of tolerance varied between the two experimental approaches.

    Area of Science:

    • Immunology
    • Developmental Biology
    • Transplantation Biology

    Background:

    • Developing host tolerance to donor cells is crucial for successful transplantation.
    • Understanding immune tolerance mechanisms is key to advancing regenerative medicine and organ transplantation.

    Purpose of the Study:

    • To investigate two distinct methods for inducing host tolerance to donor cells in avian embryos.
    • To compare the efficacy of parabiosis and embryonic limb bud transplantation in establishing immune tolerance.

    Main Methods:

    • Parabiosis: Joining chorioallantoic membranes of chicken embryos after 9 days of incubation.
    • Embryonic Limb Bud Transplants: Transferring limb buds from donor to host chicken embryos after 96 hours of incubation.
    • Comparable developmental stages were used for other species.
    Keywords:
    BIRDSCHICK EMBRYOEMBRYOLOGYEXPERIMENTAL LAB STUDYEXTREMITIESPARABIOSISTRANSPLANTATION

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    Main Results:

    • Both parabiosis and embryonic limb bud transplantation were effective in developing host tolerance to donor cells.
    • The degree of tolerance achieved differed between the two methods, indicating varying levels of efficacy.

    Conclusions:

    • Avian embryos can develop tolerance to donor cells through both parabiosis and embryonic transplantation.
    • The choice of method influences the extent of immune tolerance established, suggesting distinct underlying mechanisms.