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[Evaluation and selection of normal range calculation methods].

T Usui1

  • 1Department of Laboratory Medicine, Nagasaki University School of Medicine.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|August 1, 1992
PubMed
Summary
This summary is machine-generated.

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Evaluating normal range calculation methods is crucial. The Clinical Reference Range Program (CRRP) offers a robust solution, even with some abnormal data, unlike other methods.

Area of Science:

  • Clinical chemistry
  • Biostatistics

Context:

  • Establishing accurate normal reference ranges is essential for clinical diagnosis.
  • Existing normal range calculation methods yield variable results.
  • Data often contains a small proportion of abnormal values, complicating range determination.

Purpose:

  • To propose evaluation parameters (accuracy, precision, robustness) for normal range calculation methods.
  • To compare the distribution selection method with the Clinical Reference Range Program (CRRP).
  • To define sample size requirements based on precision.

Summary:

  • The distribution selection method, while theoretically sound, exhibits poor precision and robustness with contaminated data.
  • The Clinical Reference Range Program (CRRP) demonstrates superior robustness and applicability to data sets containing abnormal values.

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  • A novel condition for determining adequate sample size, based on precision, is introduced.

    • Impact:

    • Provides a framework for objectively evaluating normal range calculation methodologies.
    • Highlights the limitations of traditional methods when dealing with real-world clinical data.
    • Offers a more reliable method (CRRP) for establishing clinical reference ranges, improving diagnostic accuracy.