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[Factors that influence reference values].

T Nakayama1

  • 1Department of Clinical Chemistry, Toranomon Hospital, Tokyo.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|August 1, 1992
PubMed
Summary
This summary is machine-generated.

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Reference values are influenced by analytical methods, healthy person selection, and statistics. Physiological factors in healthy individuals significantly impact reference values, suggesting personalized laboratory reference ranges.

Area of Science:

  • Clinical Chemistry
  • Laboratory Medicine
  • Biostatistics

Context:

  • Establishing accurate reference values is crucial for interpreting clinical laboratory results.
  • Variability in reference values can arise from multiple factors, including analytical procedures and patient characteristics.

Purpose:

  • To review factors influencing clinical laboratory reference values.
  • To introduce a new concept of two-step reference values (basal and equivocal).

Summary:

  • Key factors affecting reference values include analytical technology, selection of healthy individuals, and statistical methods.
  • Physiological conditions in healthy individuals (age, sex, lifestyle, etc.) exert the most significant influence.
  • A two-step reference value system (basal and equivocal) is proposed to account for physiological variability.

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Impact:

  • Highlights the substantial impact of physiological variations on reference values.
  • Recommends developing laboratory-specific reference ranges using carefully selected populations.
  • Emphasizes the need for individualized reference value determination in clinical diagnostics.