Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Macroglossia in acromegaly and hypothyroidism.

A L Wittmann

    Virchows Archiv. A, Pathological Anatomy and Histology
    |April 29, 1977
    PubMed
    Summary

    Macroglossia, or enlarged tongue, was studied in patients with acromegaly and hypothyroidism. Autopsy findings revealed significant tongue enlargement in both conditions, with specific histopathological changes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Chondritis in systemic lupus erythematosus: clinical and immunopathologic studies.

    Clinical and experimental rheumatology·1987
    Same author

    Malacoplakia of the prostate following chronic urinary tract infection.

    The Journal of urology·1977
    See all related articles

    Area of Science:

    • Endocrinology
    • Pathology
    • Anatomy

    Background:

    • Macroglossia can be associated with endocrine disorders.
    • Understanding tongue size variations is important for diagnosing conditions like acromegaly and hypothyroidism.

    Purpose of the Study:

    • To investigate the histopathological features of macroglossia in acromegaly and hypothyroidism.
    • To establish baseline tongue weight in adults for comparison.

    Main Methods:

    • Autopsy examination of two patients with macroglossia (acromegaly and hypothyroidism).
    • Determination of average adult tongue weight from 20 unselected autopsies.
    • Histopathological analysis of tongue tissue.

    Main Results:

    • Tongue weight positively correlated with subject height and was greater in males.
    • Tongues in acromegaly and hypothyroidism were enlarged by at least 50%.
    • Histopathology revealed muscle fiber enlargement, epithelial thickening, and increased connective tissue.

    Conclusions:

    • Acromegaly and hypothyroidism are associated with significant macroglossia.
    • Histopathological changes in the tongue include muscle and connective tissue alterations.
    • Incidental findings like venous thrombi and cartilage were noted.

    Related Experiment Videos