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[Structural and functional parameters of the myocardium and atrial natriuretic peptide in atrial fibrillation]
Kardiologiia
|May 1, 1992
Insights
Atrial natriuretic factor levels correlate with heart conditions and atrial fibrillation. Factors like left ventricular mass and antiarrhythmic therapy influence these levels in cardiovascular patients.
Area of Science:
- Cardiology
- Biochemistry
Context:
- Investigated patients with coronary heart, rheumatic, and mitral valvular diseases, and neurocirculatory dystonia complicated by atrial fibrillation.
- Examined the plasma levels of atrial natriuretic factor (ANF).
Purpose:
- To explore the relationship between ANF plasma levels and intracardiac/systemic hemodynamic parameters.
- To understand factors influencing ANF concentration in cardiovascular disease patients with atrial fibrillation.
Summary:
- ANF levels were found to vary significantly in patients with diverse cardiac conditions and atrial fibrillation.
- Key influencing factors identified include left ventricular myocardial mass, left atrial contractility, and the intensity/efficacy of antiarrhythmic therapy.
Impact:
- Provides insights into the complex interplay of cardiac structure, function, and neurohormonal regulation in cardiovascular disease.
- Highlights potential biomarkers for assessing disease severity and treatment response in patients with atrial fibrillation.
Abstract:
The plasma level of atrial natriuretic factor and its relation to intracardiac and systemic hemodynamic parameters were examined in patients with coronary heart, rheumatic and mitral valvular diseases, neurocirculatory dystonia which were complicated by atrial fibrillation. The concentration of atrial natriuretic factor was found to vary with the left ventricular myocardial mass, left atrial contractility, antiarrhythmic therapy intensity and efficacy.