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Natriuretic peptides and the kidney: current concepts
1Department of Medicine, Joslin Diabetes Center, Boston, Massachusetts.
Kidney International. Supplement
|October 1, 1992
Summary
Natriuretic peptides, involved in salt and water balance, comprise a complex family from various organs. Their integrated actions regulate kidney function, with distinct roles for atrial and kidney-derived peptides.
Area of Science:
- Physiology
- Endocrinology
- Nephrology
Background:
- Natriuretic peptides (NP) regulate physiological responses to salt and water loading.
- Initial understanding of NP function as a single atrial peptide has evolved.
- A complex family of NPs is now recognized, originating from multiple organs.
Purpose of the Study:
- To explore the complexity of natriuretic peptide regulation.
- To differentiate the roles of various NP sources in renal function.
- To investigate the integration of NP effects on salt and water balance.
Main Methods:
- Review of existing literature on natriuretic peptides.
- Analysis of the physiological roles of different NP families.
- Examination of NP secretion sites and their functional implications.
Main Results:
- The hypothesis of a single atrial natriuretic peptide has been disproven.
- Multiple NP types are secreted from atria, ventricles, brain, and kidneys.
- Atrial NPs primarily affect glomerular function, while other sources may influence tubular function.
Conclusions:
- Natriuretic peptide regulation of renal function is complex and involves multiple peptide families.
- Distinct NP sources likely contribute to specific aspects of renal tubular and glomerular regulation.
- Further research is needed to elucidate the regulation of kidney-derived NPs and their precise roles.