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STUDIES ON THE MAMMALIAN TOXICITY OF FENTHION
Abstract:
This paper constitutes a report on mammalian toxicological investigations of fen hion, carried out as part of the WHO malaria eradication programme, and on the conclusions drawn from them. Fenthion is found to be of intermediate toxicity to the four rodent species studied. In rats the signs of poisoning develop rather slowly but persist for several days, male rats being more susceptible than females, whereas for most phosphorothionates the converse is true. The results suggest that fenthion is not simply oxidized from the P=S compound to the P=O. It has been stated that the sulfoxide and sulfone are produced before the P=S-->P=O oxidation takes place, but experiments suggest that further changes are involved. The findings are discussed in relation to the possible health hazard that might be encountered by those who have to apply fenthion as a residual spray.
Insights
Fenthion exhibits intermediate toxicity in rodents, with male rats showing higher susceptibility. Toxicological findings inform potential health risks associated with its use in malaria eradication programs.
Area of Science:
- Toxicology
- Environmental Health
- Insecticide Research
Background:
- Fenthion is an organophosphate insecticide used in WHO malaria eradication programs.
- Mammalian toxicological data is crucial for assessing insecticide safety.
Purpose of the Study:
- To report on mammalian toxicological investigations of fenthion.
- To evaluate the potential health hazards of fenthion application.
Main Methods:
- Toxicological studies were conducted on four rodent species.
- Investigations focused on the metabolic pathways and toxicity of fenthion.
Main Results:
- Fenthion demonstrated intermediate toxicity across studied rodent species.
- Male rats were more susceptible to fenthion poisoning than females.
- Metabolic pathways of fenthion appear more complex than simple oxidation.
Conclusions:
- Fenthion's toxicity profile necessitates careful consideration for human health.
- Findings contribute to risk assessment for fenthion as a residual spray.
