Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiac function in the chronically volume-overloaded canine heart.

B Wüsten, W Flameng, W Schaper

    Basic Research in Cardiology
    |March 1, 1977
    PubMed
    Summary

    In volume-overloaded hearts, early cardiac muscle changes elevate contractility. However, at stable hypertrophy, cardiac function and contractility normalize, maintaining reserve.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Response to exercise and mechanical efficiency in non-ischaemic stunning, induced by short-term rapid pacing in dogs: a role for calcium?

    Acta physiologica (Oxford, England)·2015
    Same author

    Chronic ischemic viable myocardium in man: Aspects of dedifferentiation.

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
    Same author

    Evolving Bioprosthetic Tissue Calcification Can Be Quantified Using Serial Multislice CT Scanning.

    International journal of biomaterials·2013
    Same author

    Improved endothelialization and reduced thrombosis by coating a synthetic vascular graft with fibronectin and stem cell homing factor SDF-1α.

    Acta biomaterialia·2011
    Same author

    Giant aortic aneurysm after 35 years' uneventful survival, without anticoagulation, with a Björk-Shiley aortic valve.

    The Journal of heart valve disease·2011
    Same author

    Cyclically stretching developing tissue in vivo enhances mechanical strength and organization of vascular grafts.

    Acta biomaterialia·2010

    Area of Science:

    • Cardiovascular Physiology
    • Cardiac Remodeling

    Background:

    • Chronic volume overload, such as from atrioventricular block (AV-block), induces cardiac hypertrophy.
    • Understanding cardiac function during the development and stabilization of hypertrophy is crucial.

    Purpose of the Study:

    • To evaluate cardiac function and contractility in a canine model of chronic volume overload.
    • To assess changes during the early development and established stages of cardiac hypertrophy.

    Main Methods:

    • Canine model with induced atrioventricular block to create chronic volume overload.
    • Cardiac function assessments including contractility (dP/dtmax) at varying time points (1-2 weeks and 10 weeks).
    • In situ and isolated heart evaluations to measure cardiac performance and functional reserve.

    Main Results:

    • Early in hypertrophy (1-2 weeks), contractility (dP/dtmax) was elevated at comparable loads.
    • At stable hypertrophy (10 weeks), cardiac contractility returned to normal levels.
    • The hypertrophied heart demonstrated non-depressed cardiac performance and maintained functional reserve.

    Conclusions:

    • Cardiac contractility initially increases then normalizes during the development of chronic volume overload-induced hypertrophy.
    • The established hypertrophied heart maintains normal cardiac performance and functional reserve.

    Related Experiment Videos