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[Four-stranded complexes of oligonucleotides--quadruplexes].

I A Il'icheva, V L Florent'ev

    Molekuliarnaia Biologiia
    |May 1, 1992
    PubMed
    Summary

    Guanine-rich oligonucleotides form stable four-stranded helices, with structures investigated by X-rays and spectroscopy. These quadruplexes play roles in telomere function, meiosis, and DNA replication.

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    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Structural Biology

    Context:

    • Guanine-rich sequences form stable four-stranded helices (quadruplexes).
    • These structures are investigated using X-ray crystallography and spectrographic methods.
    • Oligonucleotide quadruplexes exhibit diverse structural conformations.

    Purpose:

    • To review experimental, model, and calculation studies on oligonucleotide quadruplex formation.
    • To analyze the structural variants and biological roles of guanine-rich quadruplexes.
    • To explore quadruplexes with arbitrary sequences in replication and recombination.

    Summary:

    • The review covers the formation and structures of natural and synthetic oligonucleotide quadruplexes.
    • Three noncanonical structures of oligoguanylic acids are discussed: two four-stranded helices and a two-stranded hairpin.
    • The role of quadruplexes in telomere structure, meiosis, and DNA replication/recombination is examined.

    Impact:

    • Provides insights into the structural diversity and functional significance of oligonucleotide quadruplexes.
    • Highlights the involvement of quadruplexes in fundamental cellular processes like DNA replication and recombination.
    • Offers a comprehensive overview for researchers studying nucleic acid structures and functions.

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