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Related Experiment Videos

Nerve conduction studies in amyotrophic lateral sclerosis.

D R Cornblath1, R W Kuncl, E D Mellits

  • 1Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Muscle & Nerve
|October 1, 1992
PubMed
Summary

Nerve conduction studies (NCS) help diagnose amyotrophic lateral sclerosis (ALS). This study defines normal NCS limits in ALS patients, aiding differentiation from mimic disorders.

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Area of Science:

  • Neurology
  • Electromyography
  • Neurophysiology

Background:

  • Nerve conduction studies (NCS) are crucial for evaluating amyotrophic lateral sclerosis (ALS).
  • Distinguishing ALS from mimic disorders can be challenging, especially with severe muscle atrophy.
  • Abnormalities in conduction velocity (CV), distal latency (DL), and F-wave latency (F) require context within ALS.

Purpose of the Study:

  • To establish the normal limits of NCS parameters in patients with classic ALS.
  • To determine if NCS abnormalities exceed expected values in ALS.
  • To provide criteria for differentiating ALS from other neurological conditions using NCS.

Main Methods:

  • Prospective evaluation of NCS data from 61 clinically defined ALS patients.
  • Analysis of peroneal, median, and ulnar nerve conduction parameters (CV, DL, F, and amplitude).

Related Experiment Videos

  • Regression analysis to establish 95% confidence limits for NCS parameters as a function of distal evoked amplitude (AMP).

    • Main Results:

    • In nerves with reduced amplitude, CV rarely dropped below 80% of the lower normal limit.
    • Distal latency and F-wave latency rarely exceeded 1.25 times the upper normal limit.
    • Calculated 95% confidence limits provide expected values for CV, DL, and F based on AMP.

    Conclusions:

    • Derived NCS limits offer criteria for identifying abnormalities specific to ALS.
    • These criteria can assist in differentiating ALS from other illnesses.
    • NCS remains an integral tool in the comprehensive evaluation of ALS patients.