Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mild ischemia causes severe pathological changes in experimental diabetic nerve.

H Nukada1

  • 1Department of Medicine, University of Otago Medical School, Dunedin, New Zealand.

Muscle & Nerve
|October 1, 1992
PubMed
Summary

Diabetic nerves are more susceptible to damage from mild ischemia, or reduced blood flow. This increased vulnerability in diabetic peripheral nerves may worsen existing diabetes-related tissue abnormalities.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Skin wrinkling for the assessment of sympathetic function in the limbs.

The Australian and New Zealand journal of surgery·2000
Same author

Acute inflammatory demyelination in reperfusion nerve injury.

Annals of neurology·2000
Same author

Protein carbonyl formation and tyrosine nitration as markers of oxidative damage during ischaemia-reperfusion injury to rat sciatic nerve.

Neuroscience·1999
Same author

[Ischemic neuropathy].

Rinsho shinkeigaku = Clinical neurology·1999
Same author

Endoneurial microvascular abnormalities of sural nerve in non-diabetic chronic atherosclerotic occlusive disease.

Journal of the neurological sciences·1999
Same author

[Diabetic neuropathy: pathogenesis and treatment].

Rinsho shinkeigaku = Clinical neurology·1998

Area of Science:

  • Neuroscience
  • Endocrinology
  • Pathology

Background:

  • Nerve ischemia is a known factor in peripheral nerve damage in diabetes mellitus.
  • Diabetic neuropathy involves structural changes in peripheral nerves.

Purpose of the Study:

  • To investigate the impact of mild ischemia on sciatic nerves in a diabetic rat model.
  • To determine if diabetic nerves exhibit increased susceptibility to ischemic injury.

Main Methods:

  • Utilized streptozotocin-induced diabetic rats and control rats.
  • Administered polystyrene microspheres intraarterially to induce mild sciatic nerve microvessel occlusion.
  • Conducted morphometrical evaluation of myelinated fibers in sciatic and tibial nerves.

Main Results:

Related Experiment Videos

  • Diabetic nerves displayed severe pathological changes in myelinated fibers.
  • Nondiabetic nerves showed normal or minor structural abnormalities.
  • Morphometry revealed a higher frequency of abnormal myelinated fibers in diabetic nerves, particularly centrally.

Conclusions:

  • Diabetic nerves possess heightened morphological susceptibility to ischemia.
  • Endoneurial hypoxia likely lowers ischemic tolerance in diabetic nerves.
  • This vulnerability may exacerbate hyperglycemia-induced tissue abnormalities in diabetic peripheral nerves.