Related Experiment Video
Updated: Jun 14, 2026
05:20
Characterization of Thermal Transport in One-dimensional Solid Materials
Published on: January 26, 2014
TERATOGENIC SIGNIFICANCE OF IONIC AND FLUID IMBALANCES
Science (New York, N.Y.)
|November 22, 1963
Insights
Teratogenic agents can cause birth defects in chick embryos by creating fluid and electrolyte imbalances. Differences in normal chick serum and yolk composition help explain these teratogenic effects.
Area of Science:
- Developmental biology
- Embryology
- Teratology
Background:
- Teratogenic agents are known to induce developmental abnormalities in embryos.
- Fluid and electrolyte imbalances are implicated in the pathogenesis of certain congenital malformations.
Purpose of the Study:
- To investigate the role of serum electrolyte and fluid imbalances in teratogen-induced edema syndrome in chick embryos.
- To elucidate the contribution of normal serum and yolk ionic composition to the development of these imbalances.
Main Methods:
- Chick embryo model exposed to teratogenic agents.
- Analysis of serum and yolk electrolyte concentrations.
- Assessment of fluid balance and edema formation.
Main Results:
- Teratogenic agents induced significant serum electrolyte and fluid imbalances in chick embryos.
- These imbalances were correlated with the development of an edema syndrome.
- Significant differences in the ionic composition of serum and yolk were observed in normal versus exposed embryos.
Conclusions:
- Serum electrolyte and fluid imbalances are a key mechanism by which certain teratogens cause malformations in chick embryos.
- The inherent ionic composition of serum and yolk plays a role in susceptibility to these teratogenic effects.
Abstract:
Some agents teratogenic to the chick embryo cause serum electrolyte and fluid inmbalances which initiate an edema syndrome leading to malformations. Differences in ionic composition of serum and yolk of normal chicks help explain how these imbalances can be produced.
Related Concept Videos
02:26Molecular Comparison of Gases, Liquids, and Solids
Particles in a solid are tightly packed together (fixed shape) and often arranged in a regular pattern; in a liquid, they are close together with no regular arrangement (no fixed shape); in a gas, they are far apart with no regular arrangement (no fixed shape). Particles in a solid vibrate about fixed positions (cannot flow) and do not generally move in relation to one another; in a liquid, they move past each other (can flow) but remain in essentially constant contact; in a gas, they move...
02:39Phase Transitions: Vaporization and Condensation
The physical form of a substance changes on changing its temperature. For example, raising the temperature of a liquid causes the liquid to vaporize (convert into vapor). The process is called vaporization—a surface phenomenon. Vaporization occurs when the thermal motion of the molecules overcome the intermolecular forces, and the molecules (at the surface) escape into the gaseous state. When a liquid vaporizes in a closed container, gas molecules cannot escape. As these gas phase molecules...
02:39Phase Transitions: Melting and Freezing
Heating a crystalline solid increases the average energy of its atoms, molecules, or ions, and the solid gets hotter. At some point, the added energy becomes large enough to partially overcome the forces holding the molecules or ions of the solid in their fixed positions, and the solid begins the process of transitioning to the liquid state or melting. At this point, the temperature of the solid stops rising, despite the continual input of heat, and it remains constant until all of the solid is...
01:11Temperature and Thermal Equilibrium
Heat and temperature are essential concepts for everyone every day. The study of heat and temperature is part of an area of physics known as thermodynamics. It is not always easy to distinguish heat and temperature.
The concept of temperature has evolved from the common concepts of hot and cold. The scientific definition of temperature explains more than just our sense of hot and cold. Temperature is operationally defined as the quantity measured with a thermometer. Furthermore, temperature is...
The concept of temperature has evolved from the common concepts of hot and cold. The scientific definition of temperature explains more than just our sense of hot and cold. Temperature is operationally defined as the quantity measured with a thermometer. Furthermore, temperature is...
01:29Potential Due to a Polarized Object
A neutral atom consists of a positively charged nucleus surrounded by a negatively charged electron cloud. When placed in an external electric field, the external electric force pulls the electrons and nucleus apart, opposite to the intrinsic attraction between the nucleus and the electrons. The opposing forces balance each other with a slight shift between the center of masses of the nucleus and the electron cloud, resulting in a polarized atom. On the other hand, a few molecules, like water,...
01:29Nonideal Two-Component Liquid Solutions
Nonideal liquid solutions, also known as real solutions, do not strictly follow Raoult's law. Raoult's law is a rule of thumb in physical chemistry. However, not all mixtures adhere to this law due to varying molecular interactions. For example, in an acetone/chloroform solution, the individual vapor pressures of the components are lower than expected, resulting in a total vapor pressure below that predicted by Raoult's law, causing a negative deviation.On the other hand, in an ethanol/water...