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Immune complexes and complement catabolism in ankylosing spondylitis.

R Gabay, R H Zubler, U E Nydegger

    Arthritis and Rheumatism
    |May 1, 1977
    PubMed
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    Immune complexes were elevated in some ankylosing spondylitis patients, but C3d levels were normal. Rheumatoid arthritis patients showed higher immune complex and C3d levels.

    Area of Science:

    • Immunology
    • Rheumatology

    Background:

    • Ankylosing spondylitis (AS) is a chronic inflammatory disease.
    • Immune complexes and complement activation are implicated in rheumatic diseases.

    Purpose of the Study:

    • To investigate immune complex levels and complement activation in AS patients.
    • To compare findings with seropositive rheumatoid arthritis (RA).

    Main Methods:

    • Quantification of immune complexes using the 125I-Clq binding test in serum.
    • Measurement of C3d, a complement C3 breakdown product, in plasma.
    • Comparison with healthy blood donors and RA patients.

    Main Results:

    • Significantly increased Clq binding activity was observed in a subset of seropositive AS patients, but not in other AS patients.

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  • C3d levels were within the normal range for all AS patients studied.
  • Elevated Clq binding activity and C3d levels were prevalent in seropositive RA patients.

    • Conclusions:

    • Immune complex deposition may play a role in a subset of AS patients.
    • Complement activation marker C3d is not significantly elevated in AS.
    • Findings suggest distinct immunopathogenic mechanisms in AS compared to RA.